A new study confirms prevailing opinion that proton pump inhibitors, or PPIs, render the user more susceptible to bone fractures. Proton pump inhibitors are medications that inhibit the creation of acid in the stomach.
This study found an increased risk of fracture among new PPIs, as opposed to older acid reflux medications, known as histamine-2 receptor antagonists.
After a study last year, the Food and Drug Administration placed a warning on PPIs for their fracture risk, but then lifted the cautionary label from over-the-counter PPIs, because the latter is not meant for long-term use, and only long-term use produced a statistically significant increase of bone fractures.
The new analysis combed through 11 studies and concluded patients using PPIs increased their chances of bone fracture by 29%. Longer-term users were 30% more prone to fractures, while high dosages garnered a stunning 53% greater rate of hip fracture.
A staff physician and senior scientist on the new study, Dr. Seung-Kwon Myung, agreed with the FDA's results: "Long-term or frequent use of P.P.I.’s should be avoided."
Proton pump inhibitors inhibit proton pumps, which are molecules in the stomach that create acid. The molecules attract potassium atoms and expel hydrogen atoms, or protons, which are the ingredient necessary for stomach acid. Sometimes, stomach acid causes acid reflux, indigestion, ulcers, GERD, and other digestive disorders. PPIs are meant to reduce these conditions. Sometimes they are prescribed with antacids or with antibiotics.
As beneficial as PPIs may be for acid reflux alleviation, the results of this new research -- that PPIs increase the risk of bone fracture -- should be made clear to anyone who is prescribed PPIs, or to anyone who buys it without a prescription.
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