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Common drugs used to treat heartburn were strongly linked with hip fractures in post-menopausal women in a study released this week.
Proton pump inhibitors (PPIs) work by decreasing gastric acid production, which can otherwise induce indigestion. Unfortunately, PPIs also inhibits the body's calcium-absorptive functionality, which may weaken bones, thereby leaving one more susceptible to fractures.
The study was published in the British Medical Journal by researchers at Massachusetts General Hospital, who gathered information on 79,899 post-menopausal women between 2000 and 2008. 893 suffered hip fractures, and those who were on prolonged PPIs were at a 35% higher risk of fracture. Those women on PPI suffered 2.02 fractures per 1000 while those without PPI suffered 1.51 fractures per 1000. The longer a woman was on PPIs, the more she was in danger of fracturing her hip. Interestingly, those women who smoked or used to smoke were at a 50% higher risk. Still, hip fracture risk returned to normal after 24 months of not taking PPIs.
The FDA had initially warned against PPIs for this very reason in 2010. However, this is the first study to verify the concern.
8.9% of adult women were on PPIs in 2008, up from 6.7% in 2000.
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