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Over-the-counter painkillers like Motrin, Aleve, and Aspirin have been tied to several rare birth defects in a new study conducted by the Centers for Disease Control and Prevention (CDC). The risks remain small, but the correlation is evident.
The CDC used information available in a National Birth Defects Prevention study and published the findings in the American Journal of Obstetrics and Gynecology. The data included 15,000 women who gave birth to children with birth defects and 5,500 women who gave birth to children without.
For the children of women who took the above-mentioned painkillers, the risk of cleft palate -- a facial deformity -- rose 30-80%. The risk of spina bifida -- an improper development of the spine -- rose by 60%.
These figures, however, do not prove causation, although the correlation is striking.
Moreover, the incidence of these birth defects remain low, even if the risk is increased substantially. For example, babies born with no eyes of with small eyes that often cause blindness were three times as likely to be born to women who took Aspirin or Aleve. But this defect occurs in one of 5300 US births. Similarly, babies born with amniotic band syndrome, which often leads to deformations like clubfoot, were three times as likely to be born to women who took these painkillers during pregnancy. But this defect occurs in one of 10,000 US births.
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